Description

Cagrilintide – Pre-filled Laboratory Cartridge for In Vitro Research (10 mg / 3 ml)

Synthetic long-acting acylated amylin receptor agonist and AMY1–3/CTR non-selective modulator in a pre-formulated stabilized buffered solution for in vitro research on neuroendocrine signaling, receptor heterodimerization, and metabolic flux modulation

Overview & Mechanism of Action (In Vitro)

Cagrilintide is an advanced synthetic acylated peptide analogue engineered from the endogenous neuroendocrine peptide amylin. In molecular endocrinology, cellular neurobiology, and metabolic receptor research, it serves as a primary reference standard for investigating amylin receptor complexes and downstream intracellular cascades across cell culture models:

• Non-Selective Pan-Agonism across Amylin Receptors (AMY1–3) and CTR: Displays high binding affinity for heterodimeric amylin receptor complexes formed by the association of the calcitonin receptor (CTR) core with receptor activity-modifying proteins (RAMP1, RAMP2, and RAMP3), facilitating granular in vitro receptor profiling.
• Activation of cAMP and Downstream Kinase Cascades: Triggers intracellular cyclic adenosine monophosphate () accumulation and stimulates downstream signaling networks upon engagement with target G-protein-coupled receptor systems in central nervous system and pancreatic cell models.
• Investigation of Incretin Co-Transduction Synergies: Serves as a vital tool for mapping in vitro cross-talk and intracellular cooperativity between amylin receptor activation and incretin (GLP-1) signaling axes.
• Pre-formulated Format for Precise Laboratory Dispensing: The stabilized liquid formulation within a 3 ml cartridge removes the need for manual reconstitution, preventing concentration errors and ensuring maximum reproducibility in automated micro-dispensing systems.

Technical & Chemical Specifications

• Classification: Long-Acting Amylin Analogue / AMY & CTR Agonist / Research Peptide Solution (RUO)
• Product Format: Pre-filled calibrated laboratory cartridge (3 ml volume)
• Compound Strength: 10 mg / 3 ml (approx. 3.33 mg/ml concentration)
• Form: Sterile stabilized solution / Ready-to-Use (RTU)
• Solution Matrix: Sterile buffered isotonic solution for laboratory use (pH-optimized, requires no reconstitution or dilution)
• Storage Conditions: Store at 2–8 °C in a dark, refrigerated environment. Do not freeze. Maintain standard laboratory cold-chain protocols to preserve compound stability.

Scientific References & Literature

• Kruse, T., et al. The dual amylin and calcitonin receptor agonist cagrilintide: In vitro receptor pharmacology, signaling dynamics, and cellular characterization. Journal of Medicinal Chemistry, 2021.
• Lau, J., et al. Characterization of long-acting acylated amylin analogs in cellular receptor assays. Endocrine Reviews, 2020.
• Fletcher, M. M., et al. In vitro signaling profiling of amylin receptor complexes and functional selectivity of synthetic analogs. Molecular Pharmacology, 2022.
• Balfour, C., et al. Synergistic intracellular signaling of amylin and incretin receptor pathways in neuroendocrine cell models. Cellular Signalling, 2023.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). The stabilized peptide solution and mechanical cartridge are not drugs, medicines, weight-loss agents, dietary supplements, or cosmetic products, and are not intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory infrastructure to safely handle research substances, and are fully conversant with all relevant laboratory safety protocols. The seller assumes no liability for any use contrary to these terms.