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DSIP

DSIP

From 19,90 €

  • Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only / in vitro). It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.
  • Form & Contents: Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.
  • Recommended Storage: To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2–8 °C (recommended at -20 °C for long-term storage).
  • Illustrative Product Image: Product images are for illustrative purposes only. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.
Product code: DS5 Category:
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Description

DSIP

Synthetic nonapeptide for in vitro research on sleep architecture modulation, neuroendocrine homeostasis, and antioxidant enzymatic activity

Overview & Mechanism of Action (In Vitro)

DSIP (Delta Sleep-Inducing Peptide) is a synthetic nonapeptide with the sequence (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu), originally isolated from mammalian cerebral venous blood during induced slow-wave sleep. In biochemical, neurobiological, and endocrinological research, it serves as a specialized molecular model for studying neuromodulatory processes and physiological stress regulation:

  • Modulation of GABAergic & Glutamatergic Neurotransmission: Investigating inhibitory and excitatory synaptic transmission in primary neuronal cultures, focusing on the coordination of slow-wave (delta) oscillations in neural networks.
  • Neuroendocrine HPA Axis Regulation: Analyzing the modulation of corticotropin (ACTH), luteinizing hormone (LH), and somatotropin (GH) release in isolated pituitary cell assays.
  • Antioxidant & Cytoprotective Enzymatic Signaling: Monitoring the activation of superoxide dismutase (SOD) and glutathione peroxidase (GPx), alongside the reduction of lipid peroxidation markers in cellular models exposed to oxidative stress.

In laboratory media, as a linear unprotected nonapeptide, it requires standard stability monitoring and protection against endogenous peptidase degradation.

Technical & Chemical Specifications

  • Classification: Research Neuropeptide / Neuromodulatory Regulator
  • Amino Acid Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
  • Form: Sterile lyophilized white powder (cake)
  • Molecular Weight Identification: Confirmed via Mass Spectrometry (MS)
  • Recommended Reconstitution Solvent: Sterile bacteriostatic water or phosphate-buffered saline (PBS)
  • Storage Conditions: Store long-term at -20 °C in a dry, dark environment. Following reconstitution, keep refrigerated at 2–8 °C and utilize within standard experimental protocol timelines.

Scientific References & Literature

  • Schoenenberger, G. A., & Monnier, M. Characterization of a delta-electroencephalogram(-sleep)-inducing peptide. Proceedings of the National Academy of Sciences, 1977.
  • Graf, M. V., & Kastin, A. J. Delta-sleep-inducing peptide (DSIP): A review of its physiological and biochemical actions. Peptides, 1984.
  • Kovalzon, V. M., & Strekalova, T. V. Delta sleep-inducing peptide (DSIP): A still unresolved riddle. Journal of Neurochemistry, 2006.
  • Prudchenko, I. A., et al. Synthetic analogs of DSIP and their biological stability in model systems. Russian Journal of Bioorganic Chemistry, 1993.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

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