• Fast shipping across Europe
  • High-quality and 100% pure peptides for research purposes
IGF1 LR3

IGF1 LR3

From 30,90 €

  • Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only / in vitro). It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.
  • Form & Contents: Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.
  • Recommended Storage: To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2–8 °C (recommended at -20 °C for long-term storage).
  • Illustrative Product Image: Product images are for illustrative purposes only. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.
Product code: IG01 Category:
Share on social media

Description

IGF-1 LR3

Recombinant analogue of human insulin-like growth factor-1 with an N-terminal extension and Arg3 substitution for in vitro research on IGF-1R activation, mitogenesis, protein synthesis, and PI3K/Akt/mTOR signaling pathways

Overview & Mechanism of Action (In Vitro)

IGF-1 LR3 (Long Arg3 Insulin-like Growth Factor-1) is a synthetic recombinant analogue of native human IGF-1 consisting of 83 amino acids. It features a glutamic acid to arginine substitution at position 3 (Glu3→Arg3) alongside a 13-amino acid N-terminal extension peptide sequence. These structural modifications drastically decrease affinity for inhibitory insulin-like growth factor-binding proteins (IGFBPs), ensuring significantly elevated free peptide availability for receptor interaction and extending its biological half-life in culture media. In cellular biology, tissue engineering, and oncology models, it serves as a primary reference for investigating growth factor cascades:

  • Elevated Free Bioavailability & IGFBP Resistance: Marked reduction in affinity for regulatory proteins IGFBP-1 through IGFBP-6, preventing rapid neutralization and ensuring sustained receptor access in vitro.
  • IGF-1R Receptor Activation & Transphosphorylation: Binding to the receptor tyrosine kinase (IGF-1R) induces cytoplasmic auto-phosphorylation and downstream recruitment of insulin receptor substrates (IRS-1, IRS-2).
  • Upregulation of the PI3K / Akt / mTOR Pathway: Stimulation of anabolic signaling cascades promoting p70S6 kinase phosphorylation, mRNA translation initiation, cellular protein synthesis, and attenuation of the ubiquitin-proteasome proteolytic machinery.
  • Mitogenic Progression via MAPK / ERK Signaling: Induction of cell cycle transition from the G1 to S phase, activation of myoblast proliferation, and suppression of apoptotic cascades in primary cell lines.

Technical & Chemical Specifications

  • Classification: Research Peptide / Extended-Action IGF-1 Analogue (Long Arg3-IGF-1)
  • Amino Acid Sequence: 83-amino acid recombinant polypeptide with 3 intramolecular disulfide bonds
  • Form: Sterile lyophilized white powder (cake)
  • Component Identification: Verified via Mass Spectrometry (MS) and analytical HPLC
  • Recommended Reconstitution Solvent: Sterile 10mM–100mM acetic acid solution, sterile bacteriostatic water, or sterile phosphate-buffered saline (PBS)
  • Storage Conditions: Store long-term at -20 °C in a dry, dark environment. Following reconstitution, keep refrigerated at 2–8 °C in accordance with standard laboratory protocols.

Scientific References & Literature

  • Francis, G. L., et al. Novel recombinant analogues of insulin-like growth factor-1 (IGF-1) with altered affinities for IGF-binding proteins. Biochemical Journal, 1992.
  • Tomas, F. M., et al. Greater potency of IGF-I analogues than IGF-I in catabolic states is associated with altered binding to IGF-binding proteins. Journal of Endocrinology, 1995.
  • Clemmons, D. R. Role of insulin-like growth factor binding proteins in controlling IGF actions in target cells. Endocrine Reviews, 1997.
  • Ballard, F. J., et al. Biological actions and structural characteristics of Long Arg3-IGF-1 in cell culture and experimental systems. Regulatory Peptides, 1996.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

Latest products

Get 10% Off Your First Order

Subscribe to our newsletter and we will immediately send you a discount code for your first order of research materials. Get exclusive access to special offers, restock alerts, and expert updates.