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NAD +

NAD +

From 19,90 €

  • Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only / in vitro). It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.
  • Form & Contents: Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.
  • Recommended Storage: To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2–8 °C (recommended at -20 °C for long-term storage).
  • Illustrative Product Image: Product images are for illustrative purposes only. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.
Product code: NJ3100 Category:
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Description

NAD+

Synthetic dinucleotide coenzyme for in vitro research on cellular metabolism, redox balance, and sirtuin enzymatic signaling

Overview & Mechanism of Action (In Vitro)

NAD+ (β-Nicotinamide Adenine Dinucleotide) is an essential cellular coenzyme composed of two nucleotides joined through their phosphate groups. In biochemical, molecular, and cellular research, it serves as a critical electron acceptor in redox reactions and an indispensable co-substrate for specialized enzyme families:

  • Coenzyme Function in Oxidation-Reduction Cascades: Investigating electron transfer in glycolysis, the tricarboxylic acid (TCA) cycle, and mitochondrial oxidative phosphorylation via reversible transitions between oxidized (NAD+) and reduced (NADH) states.
  • Activation of Sirtuin Enzyme Class (SIRT1–SIRT7): Monitoring NAD+-dependent deacylation and deacetylation of histone and non-histone proteins affecting epigenetic transcription and mitochondrial biogenesis in cell models.
  • PARP (Poly-ADP-Ribose Polymerase) Activity: Studying DNA double-strand break repair cascades and cellular responses to genotoxic stress, where NAD+ serves as an ADP-ribose donor.

Due to its chemical structure, the molecule in lyophilized form is sensitive to moisture and elevated temperatures, requiring strict control over pH and assay media temperature in experimental protocols to prevent spontaneous pyrophosphate bond hydrolysis.

Technical & Chemical Specifications

  • Classification: Research Biochemical / Coenzyme (Dinucleotide)
  • Chemical Name: β-Nicotinamide Adenine Dinucleotide (Oxidized form)
  • Form: Sterile lyophilized white powder (cake)
  • Molecular Weight Identification: Confirmed via Mass Spectrometry (MS)
  • Recommended Reconstitution Solvent: Sterile bacteriostatic water, sterile deionized water, or physiological saline (maintaining neutral to slightly acidic pH is recommended)
  • Storage Conditions: Store long-term at -20 °C in a dry, dark environment. Following reconstitution, keep refrigerated at 2–8 °C and utilize within standard experimental protocol timelines.

Scientific References & Literature

  • Canto, C., et al. NAD+ metabolism and the control of energy homeostasis: A balancing act between mitochondria and the nucleus. Cell Metabolism, 2015.
  • Imai, S., & Guarente, L. NAD+ and sirtuins in aging and disease: Molecular mechanisms and cellular pathways. Trends in Cell Biology, 2014.
  • Verdin, E. NAD+ in aging, metabolism, and neurodegeneration: Molecular biology of cellular energy signaling. Science, 2015.
  • Rajman, L., et al. Therapeutic and experimental potential of NAD-boosting molecules: In vitro biochemical insights. Cell Metabolism, 2018.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

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