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GHRP - 2 5mg

GHRP – 2 5mg

19,90 €

  • Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only / in vitro). It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.
  • Form & Contents: Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.
  • Recommended Storage: To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2–8 °C (recommended at -20 °C for long-term storage).
  • Illustrative Product Image: Product images are for illustrative purposes only. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.
Product code: G25 Category:

10 in stock

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Description

GHRP-2

Synthetic hexapeptide for in vitro research on growth hormone secretagogue receptor (GHS-R1a) signaling

Overview & Mechanism of Action (In Vitro)

GHRP-2 (Growth Hormone Releasing Peptide-2, Pralmorelin) is a synthetic oligopeptide consisting of 6 amino acids (sequence D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2). In biochemical and endocrinological research, it serves as a model peptide secretagogue investigated for its selective affinity for the ghrelin receptor:

  • Activation of GHS-R1a Receptor: Binding to the G-protein coupled receptor (GHS-R1a) on isolated pituitary cell lines, leading to downstream activation of phospholipase C (PLC).
  • Intracellular Calcium Cascades: Monitoring of calcium ion (Ca2+) mobilization from the endoplasmic reticulum via the IP3 / DAG pathway in primary somatotrope cell cultures.
  • Interactions with Ghrelinergic Pathways: Analysis of receptor binding kinetics and competitive displacement assays against the endogenous ligand (acylated ghrelin) without altering non-targeted hormonal signaling axes.

The incorporation of D-amino acids (D-Ala, D-2-Nal, D-Phe) alongside C-terminal amidation confers pronounced enzymatic stability against tissue endopeptidases and aminopeptidases in experimental settings.

Technical & Chemical Specifications

  • Classification: Research Peptide / GHS-R1a Receptor Agonist (Ghrelin Mimetic)
  • Amino Acid Sequence: D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2
  • Form: Sterile lyophilized white powder (cake)
  • Molecular Weight Identification: Confirmed via Mass Spectrometry (MS)
  • Recommended Reconstitution Solvent: Sterile bacteriostatic water or phosphate-buffered saline (PBS)
  • Storage Conditions: Store long-term at -20 °C in a dry, dark environment. Following reconstitution, keep refrigerated at 2–8 °C and utilize within standard experimental protocol timelines.

Scientific References & Literature

  • Bowers, C. Y., et al. Structure-activity relationships of synthetic growth hormone-releasing peptides. Endocrinology, 1991.
  • Howard, A. D., et al. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science, 1996.
  • Smith, R. G., et al. Peptidomimetic regulation of growth hormone secretagogue receptor signaling in cellular models. Endocrine Reviews, 2005.
  • Kojima, M., et al. Ghrelin and the GHS-R1a signaling network: Comparative analysis of synthetic secretagogues. Journal of Molecular Endocrinology, 2008.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

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