Description

SLU-PP-332 – Research Capsules for Laboratory Purposes (250 mcg / capsule, 60 count)

Synthetic selective pan-agonist of estrogen-related receptors (ERR$alpha$, ERR$beta$, ERR$gamma$) in a solid analytical matrix for in vitro research on mitochondrial biogenesis, oxidative phosphorylation, cellular energy metabolism, and myocyte phenotypic modulation

Overview & Mechanism of Action (In Vitro)

SLU-PP-332 is a potent, synthetic small molecule developed as a selective pan-agonist of estrogen-related receptors (Estrogen-Related Receptors – ERR$alpha$, ERR$beta$, ERR$gamma$). In cellular physiology, molecular biology, and metabolic research, it serves as a primary reference standard for investigating transcriptional programs governing oxidative metabolism, mitochondrial biogenesis, and metabolic fuel switching in cell culture models:

• Pan-Agonism of the ERR Receptor Family: Binds to orphan nuclear receptors of the ERR family (displaying high potency at the ERR$alpha$ isoform) and stimulates their transcriptional activity without cross-reacting with classical estrogen receptors (ER$alpha$, ER$beta$).
• Stimulation of Mitochondrial Biogenesis & OXPHOS Capacity: Activates downstream genetic programs dependent on the PGC-1$alpha$ coactivator, leading to increased expression of TCA cycle enzymes, electron transport chain complexes (I–V), and mitochondrial mass in primary myocyte cultures in vitro.
• Fatty Acid Oxidation (FAO) Pathway Upregulation: Induces the transcription of essential metabolic enzymes (such as CPT-1b and MCAD), thereby elevating β-oxidation rates and basal oxygen consumption rates (OCR) in experimental cell lines.
• Induction of an Oxidative Myotube Phenotype: Modulates the expression profile of contractile proteins toward slow-twitch oxidative muscle fiber markers (types I/IIa) in laboratory myotube models.

Technical & Chemical Specifications

• Classification: Selective Pan-ERR Agonist / Small Molecule Standard in Solid Matrix (RUO)
• Chemical Name: 2-[(4-chlorophenyl)methyl]-1,3-benzothiazole-6-carboxylic acid
• Molecular Formula: C15H10ClNO2S
• Molecular Weight: 303.76 g/mol
• Active Content: 250 mcg (0.25 mg) per capsule (±2%)
• Packaging Unit: 60 research capsules in a laboratory container with integrated desiccant
• Form: Solid reagent matrix / encapsulated standard
• Component Identification: Verified via Analytical HPLC and Mass Spectrometry (MS / NMR)
• Recommended Reconstitution Protocol: Capsule contents are intended for dissolution in suitable laboratory solvents (e.g., DMSO for concentrated stock solutions or sterile assay buffers) to prepare calibrated concentrations for in vitro cell assays.
• Storage Conditions: Store at 15–25 °C in a dry, dark environment in the tightly sealed original container with desiccant. For long-term archiving of analytical standards, storage at -20 °C is recommended.

Scientific References & Literature

• Billingslea, E. R., et al. A small molecule pan-ERR agonist stimulates cellular mitochondrial biogenesis and oxidative capacity in vitro. ACS Chemical Biology, 2022.
• Kamei, Y., et al. Regulation of skeletal muscle oxidative metabolism and mitochondrial gene expression by estrogen-related receptors. Cell Metabolism, 2020.
• Eichner, L. J., & Giguère, V. Estrogen-related receptors (ERRs): A new dawn in transcriptional control of cellular energy metabolism. Physiological Reviews, 2011.
• Fan, W., & Evans, R. M. Exercise mimetics: Impact on transcriptional pathways of cellular bioenergetics and mitochondrial remodeling in vitro. Cell, 2017.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.