Description

AOD-9604 – Pre-filled Laboratory Cartridge for In Vitro Research (10 mg / 3 ml)

Synthetic -terminal biomimetic fragment of human growth hormone (hGH 176-191 with an -terminal tyrosine addition and disulfide bridge) in a pre-formulated stabilized buffered solution for in vitro research on selective lipolysis, lipogenesis inhibition, -adrenergic signaling cascades, and chondrogenic differentiation without glycemic or IGF-1 interference

Overview & Mechanism of Action (In Vitro)

AOD-9604 (Advanced Obesity Drug-9604) is a synthetic 16-amino acid peptide derived from the C-terminal lipolytic domain of human growth hormone (hGH 177-191), featuring an added N-terminal tyrosine residue for conformational stabilization and an intramolecular disulfide bond (). In molecular endocrinology, cellular biology, and metabolic biochemistry, it serves as a primary reference standard for investigating lipid metabolic pathways isolated from systemic somatotropic and mitogenic actions:

• Selective Lipolytic Activation in Adipocytes: Stimulates intracellular triglyceride breakdown in cultured primary white adipocytes by activating hormone-sensitive lipase (HSL) and inducing perilipin phosphorylation in vitro.
• Direct Inhibition of Lipogenesis & Lipid Accumulation: Downregulates key lipogenic enzymes, including acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS), attenuating preadipocyte differentiation and intracellular lipid storage in vitro.
• Absence of Glycemic & Mitogenic Interference: Does not interact with classical growth hormone receptors in pathways that induce peripheral insulin resistance, hyperglycemia, or mitogenic IGF-1 transcription across cell lines.
• Support of Chondrogenesis & Extracellular Matrix Synthesis: In primary chondrocyte cultures, it promotes proteoglycan accumulation and type II collagen transcription, serving as a valuable tool for joint tissue regeneration models in vitro.
• Pre-formulated Format for Precise Laboratory Dispensing: The stabilized liquid formulation within a 3 ml cartridge eliminates manual reconstitution steps, ensuring exceptional homogeneity and concentration consistency for automated micro-dispensing systems.

Technical & Chemical Specifications

• Classification: Lipolytic hGH Fragment Analogue / Chondrogenic Modulator / Research Peptide Solution (RUO)
• Product Format: Pre-filled calibrated laboratory cartridge (3 ml volume)
• Compound Strength: 10 mg / 3 ml (approx. 3.33 mg/ml concentration)
• Amino Acid Sequence:  (cyclic disulfide )
• Chemical Name:
• Molecular Formula:
• Molecular Weight:
• Form: Sterile stabilized clear solution / Ready-to-Use (RTU)
• Solution Matrix: Sterile buffered isotonic solution for laboratory use (pH-optimized, requires no reconstitution or dilution)
• Compatibility: Compatible with standard laboratory dispensing pens and micro-dispensers for 3 ml cartridges (dispensing pen/injector is not included in the package)
• Storage Conditions: Store at 2–8 °C in a dark, refrigerated environment. Do not freeze. Maintain standard laboratory cold-chain protocols to preserve compound stability.

Scientific References & Literature

• Ng, F. M., et al. A metabolic study of the lipolytic fragment of human growth hormone (AOD9604) in cellular systems and tissue cultures. Metabolism: Clinical and Experimental, 2000.
• Heffernan, M. A., et al. The effects of human GH and its lipolytic fragment AOD9604 on lipid metabolism, lipogenesis, and adipose tissue signaling in vitro. Endocrinology, 2001.
• Kwon, D. R., & Park, G. Y. Effect of intra-articular injection of AOD9604 with hyaluronic acid on cartilage regeneration and chondrocyte proliferation in vitro and in vivo. Stem Cells and Development, 2015.
• Rowan, W. C., et al. Structural and functional dissociation of growth and metabolic actions of human growth hormone fragments in cellular assays. International Journal of Peptide and Protein Research, 1995.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). The stabilized peptide solution and mechanical cartridge are not drugs, medicines, fat burners, weight-loss products, dietary supplements, or medical devices, and are not intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory infrastructure to safely handle research substances, and are fully conversant with all relevant laboratory safety protocols. The seller assumes no liability for any use contrary to these terms.