Description

CJC-1295 with DAC – Pre-filled Laboratory Cartridge for In Vitro Research (5 mg / 3 ml)

Long-acting synthetic GHRH peptide analogue bioconjugated with DAC (Drug Affinity Complex / maleimidopropionyl) in a pre-formulated stabilized buffered solution for in vitro research on serum albumin-binding kinetics, continuous GHRH receptor stimulation, cAMP/PKA signaling, and prolonged growth hormone transcription

Overview & Mechanism of Action (In Vitro)

CJC-1295 with DAC (Drug Affinity Complex) is an advanced 30-amino acid synthetic peptide analogue of growth hormone-releasing hormone (GHRH). Unlike its non-DAC counterpart, it features a covalently attached reactive maleimidopropionyl group via a C-terminal lysine linker. This functional moiety enables stable bioconjugation with the free thiol () of serum albumin. In molecular endocrinology, pharmacokinetics, and cellular physiology, it serves as a key reference standard for studying extended receptor activation profiles and enzymatic resistance:

• Covalent Albumin Bioconjugation In Vitro: The maleimide functional group selectively reacts with endogenous albumin within cell culture media and serum solutions, yielding a macromolecular complex resistant to dipeptidyl peptidase-4 (DPP-4) and neutral endopeptidase (NEP) cleavage.
• Continuous GHRH Receptor Activation: Sustained engagement with the -coupled GHRH receptor on pituitary somatotrophs induces prolonged adenylate cyclase activity and persistent intracellular cyclic adenosine monophosphate () accumulation.
• Extended Transcription & Growth Hormone Synthesis: Promotes prolonged CREB transcription factor phosphorylation and continuous expression of GH mRNA alongside downstream IGF-1 transcription across long-term cell cultures.
• Comparative Pharmacokinetic Model In Vitro: Serves as a standard benchmark for evaluating differences between pulsatile receptor stimulation (peptides without DAC) and sustained exposure kinetics (DAC conjugates).
• Pre-formulated Format for Precise Laboratory Dispensing: The stabilized liquid formulation within a 3 ml cartridge eliminates manual reconstitution variability, ensuring exceptional homogeneity and concentration consistency for automated and semi-automated micro-dispensing systems.

Technical & Chemical Specifications

• Classification: Long-Acting GHRH Analogue / Tetrasubstituted Peptide with DAC / Research Peptide Solution (RUO)
• Product Format: Pre-filled calibrated laboratory cartridge (3 ml volume)
• Compound Strength: 5 mg / 3 ml (approx. 1.67 mg/ml concentration)
• Amino Acid Sequence:
• Chemical Name: Tetrasubstituted GHRH(1-29)-Lys30(Maleimidopropionyl)-
• Molecular Formula:
• Molecular Weight:
• Form: Sterile stabilized clear solution / Ready-to-Use (RTU)
• Solution Matrix: Sterile buffered isotonic solution for laboratory use (pH-optimized, requires no reconstitution or dilution)
• Compatibility: Compatible with standard laboratory dispensing pens and micro-dispensers for 3 ml cartridges (dispensing pen/injector is not included in the package)
• Storage Conditions: Store at 2–8 °C in a dark, refrigerated environment. Do not freeze. Maintain standard laboratory cold-chain protocols to preserve compound stability.

Scientific References & Literature

• Teichman, S. L., et al. Prolonged stimulation of growth hormone and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GHRH, in cellular and clinical assays. Journal of Clinical Endocrinology & Metabolism, 2006.
• Jette, L., et al. hGRF1-29-albumin bioconjugates: In vitro stability and sustained receptor binding kinetics mediated by maleimidopropionyl conjugation. Endocrinology, 2005.
• Alba, M., et al. In vitro comparison of GHRH analogs and secretagogues on somatotroph signaling and continuous exposure kinetics. Neuroendocrinology, 2004.
• Campbell, R. M., et al. Enhanced stability and biological activity of tetrasubstituted GHRH analogs in enzymatic degradation models. Peptides, 1997.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). The stabilized peptide solution and mechanical cartridge are not drugs, medicines, muscle-building agents, weight-loss products, dietary supplements, or medical devices, and are not intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory infrastructure to safely handle research substances, and are fully conversant with all relevant laboratory safety protocols. The seller assumes no liability for any use contrary to these terms.