Description

GHK-Cu – Pre-filled Laboratory Cartridge for In Vitro Research (100 mg / 3 ml)

Highly purified copper tripeptide complex (glycyl-L-histidyl-L-lysine copper(II) / GHK-Cu) in a pre-formulated stabilized buffered solution for in vitro research on collagen and elastin gene expression, MMP/TIMP modulation, extracellular matrix remodeling, and antioxidant enzyme cascades

Overview & Mechanism of Action (In Vitro)

GHK-Cu is a naturally occurring tripeptide with a high binding affinity for divalent copper ions (). In cell biology, experimental dermatology, and tissue engineering, it serves as a primary reference standard for investigating extracellular matrix synthesis, structural remodeling, and epigenetic gene modulation across cultured cell models:

• Stimulation of Collagen, Elastin & Glycosaminoglycan Synthesis: In primary cultures of human dermal fibroblasts, it induces transcription and biosynthesis of procollagen type I, collagen type III, tropoelastin, and hyaluronic acid in vitro.
• Modulation of Tissue Remodeling & MMP/TIMP Balance: Regulates the expression of matrix metalloproteinases (MMP-1, MMP-2) alongside their tissue inhibitors (TIMP-1, TIMP-2), supporting balanced structural remodeling and matrix integrity.
• Antioxidant Pathway Activation & Cytoprotection: Stimulates superoxide dismutase (SOD) synthesis and downregulates pro-inflammatory cytokine expression (including TGF- and TNF-) in cell models subjected to oxidative stress.
• Support of Endothelial Cell Motility & Angiogenesis: Upregulates vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), promoting endothelial cell migration and capillary-like network formation in vitro.
• Pre-formulated Format for Precise Laboratory Dispensing: The stabilized liquid formulation within a 3 ml cartridge eliminates manual reconstitution steps, preventing concentration errors and ensuring maximum reproducibility across automated micro-dispensing systems.

Technical & Chemical Specifications

• Classification: Copper Tripeptide Complex / Extracellular Matrix Modulator / Research Solution (RUO)
• Product Format: Pre-filled calibrated laboratory cartridge (3 ml volume)
• Compound Strength: 100 mg / 3 ml (approx. 33.33 mg/ml concentration)
• Amino Acid Sequence: Gly-His-Lys- (copper(II) glycyl-L-histidyl-L-lysinate)
• Molecular Formula:
• Molecular Weight:
• Form: Sterile stabilized characteristic blue solution / Ready-to-Use (RTU)
• Solution Matrix: Sterile buffered isotonic solution for laboratory use (pH-optimized, requires no reconstitution or dilution)
• Compatibility: Compatible with standard laboratory dispensing pens and micro-dispensers for 3 ml cartridges (dispensing pen/injector is not included in the package)
• Storage Conditions: Store at 2–8 °C in a dark, refrigerated environment. Do not freeze. Maintain standard laboratory cold-chain protocols to preserve compound stability.

Scientific References & Literature

• Pickart, L., et al. The human tri-peptide GHK and tissue remodeling: In vitro mechanisms of gene modulation, collagen synthesis, and anti-inflammatory signaling. Journal of Biomaterials Science, Polymer Edition, 2008.
• Pickart, L., & Margolina, A. Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data. International Journal of Molecular Sciences, 2018.
• Maquart, F. X., et al. In vitro stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. FEBS Letters, 1988.
• Simeon, A., et al. Expression of glycosaminoglycans and small proteoglycans in human fibroblast cultures stimulated with GHK-Cu. Journal of Investigative Dermatology, 2000.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). The stabilized solution and mechanical cartridge are not drugs, medicines, anti-aging agents, cosmetic formulations, dietary supplements, or medical devices, and are not intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory infrastructure to safely handle research substances, and are fully conversant with all relevant laboratory safety protocols. The seller assumes no liability for any use contrary to these terms.