Description

SS-31 – Pre-filled Laboratory Cartridge for In Vitro Research (50 mg / 3 ml)

Synthetic mitochondria-targeted tetrapeptide (Elamipretide / D-Arg-Dmt-Lys-Phe-NH2) in a pre-formulated stabilized buffered solution for in vitro research on cardiolipin stabilization, mitochondrial bioenergetics, ROS reduction, and mPTP opening inhibition

Overview & Mechanism of Action (In Vitro)

SS-31 (also designated as Elamipretide or the Szeto-Schiller peptide) is a synthetic bioactive tetrapeptide engineered with alternating aromatic and basic amino acid motifs that facilitate selective concentration at the inner mitochondrial membrane (IMM). In mitochondrial biology, cellular bioenergetics, and oxidative stress research, it serves as a primary reference standard for investigating mitochondrial structural integrity and respiratory chain kinetics across cultured cell models:

• Selective Association & Stabilization of Cardiolipin: Selectively interacts with cardiolipin on the inner mitochondrial membrane through electrostatic and hydrophobic forces, preventing lipid peroxidation and preserving cristae curvature in vitro.
• Optimization of the Electron Transport Chain (ETC): Maintains structural stability of electron transport supercomplexes (specifically Complexes I, III, and IV) and cytochrome c, enhancing oxidative phosphorylation efficiency and ATP synthesis across cellular assays.
• Suppression of Mitochondrial ROS Generation: Markedly attenuates electron leakage and reactive oxygen species (ROS) formation at their primary source of generation, shielding cellular DNA and functional proteins from oxidative modifications in vitro.
• Inhibition of the Mitochondrial Permeability Transition Pore (mPTP): Prevents collapse of the mitochondrial membrane potential () and blocks cytochrome c efflux into the cytosol in cell cultures challenged by hypoxia or ischemia-reperfusion stress.
• Pre-formulated Format for Precise Laboratory Dispensing: The stabilized liquid formulation within a 3 ml cartridge eliminates manual dilution variability, ensuring exceptional homogeneity and concentration consistency for automated and semi-automated micro-dispensing systems.

Technical & Chemical Specifications

• Classification: Mitochondria-Targeted Tetrapeptide / Cardiolipin Modulator / Research Peptide Solution (RUO)
• Product Format: Pre-filled calibrated laboratory cartridge (3 ml volume)
• Compound Strength: 50 mg / 3 ml (approx. 16.67 mg/ml concentration)
• Amino Acid Sequence: D-Arg-Dmt-Lys-Phe- (where Dmt = 2′,6′-dimethyltyrosine)
• Molecular Formula:
• Molecular Weight:  (free base)
• Form: Sterile stabilized solution / Ready-to-Use (RTU)
• Solution Matrix: Sterile buffered isotonic solution for laboratory use (pH-optimized, requires no reconstitution or dilution)
• Compatibility: Compatible with standard laboratory dispensing pens and micro-dispensers for 3 ml cartridges (dispensing pen/injector is not included in the package)
• Storage Conditions: Store at 2–8 °C in a dark, refrigerated environment. Do not freeze. Maintain standard laboratory cold-chain protocols to preserve compound stability.

Scientific References & Literature

• Szeto, H. H. First-in-class cardiolipin-protective compound as a therapeutic approach to optimize mitochondrial bioenergetics in cellular models. British Journal of Pharmacology, 2014.
• Birk, A. V., et al. The mitochondrial-targeted peptide SS-31 directly interacts with cardiolipin to protect mitochondrial cristae structure and bioenergetics in vitro. Proceedings of the National Academy of Sciences (PNAS), 2013.
• Dai, D. F., et al. Mitochondrial-targeted antioxidant peptide SS-31 rescues mitochondrial dysfunction and improves cell survival in aged cardiac models in vitro. Cell Cycle, 2013.
• Zhao, K., et al. Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit ROS production and apoptosis in cultured cells. Journal of Biological Chemistry, 2004.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). The stabilized peptide solution and mechanical cartridge are not drugs, medicines, weight-loss agents, dietary supplements, or cosmetic products, and are not intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory infrastructure to safely handle research substances, and are fully conversant with all relevant laboratory safety protocols. The seller assumes no liability for any use contrary to these terms.