Description

CJC-1295 no DAC – Pre-filled Laboratory Cartridge for In Vitro Research (10 mg / 3 ml)

Synthetic tetrasubstituted GHRH analogue (Mod GRF 1-29) in a pre-formulated stabilized buffered solution for in vitro research on GHRH receptor activation, cAMP/PKA signaling cascades, growth hormone transcription, and physiological pulsatility kinetics

Overview & Mechanism of Action (In Vitro)

CJC-1295 no DAC (also designated as Modified GRF 1-29) is a synthetic 29-amino acid peptide analogue derived from growth hormone-releasing hormone (GHRH). Featuring targeted four-point amino acid substitutions at positions 2, 8, 15, and 27, it exhibits substantially increased enzymatic stability against dipeptidyl peptidase-4 (DPP-4) cleavage compared to native GHRH 1-29. In molecular endocrinology and cellular physiology, it serves as an essential research standard for investigating the somatotropic axis:

• Selective GHRH Receptor Binding: Binds with high affinity to transmembrane GHRH receptors coupled to  proteins on pituitary somatotrophs in primary cell cultures.
• Adenylate Cyclase Pathway Activation: Promotes intracellular cyclic adenosine monophosphate () accumulation and subsequent protein kinase A (PKA) activation, leading to CREB transcription factor phosphorylation in vitro.
• Stimulation of Growth Hormone Transcription & Synthesis: Induces growth hormone mRNA expression and supports vesicular packaging and pulsatile exocytosis without disrupting natural feedback loops.
• Preservation of Physiological Pulsatility: Lacking the Drug Affinity Complex (DAC), it does not bind blood proteins, enabling precise in vitro modeling of natural pulse kinetics and somatostatin-mediated counter-regulation.
• Pre-formulated Format for Precise Laboratory Dispensing: The stabilized liquid matrix within a 3 ml cartridge eliminates manual reconstitution steps, ensuring exceptional homogeneity and concentration consistency for automated micro-dispensing systems.

Technical & Chemical Specifications

• Classification: Synthetic GHRH Analogue / Mod GRF 1-29 / Research Peptide Solution (RUO)
• Product Format: Pre-filled calibrated laboratory cartridge (3 ml volume)
• Compound Strength: 10 mg / 3 ml (approx. 3.33 mg/ml concentration)
• Amino Acid Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-
• Chemical Name: Modified Growth Hormone Releasing Factor 1-29 (Mod GRF 1-29)
• Molecular Formula:
• Molecular Weight:
• Form: Sterile stabilized clear solution / Ready-to-Use (RTU)
• Solution Matrix: Sterile buffered isotonic solution for laboratory use (pH-optimized, requires no reconstitution or dilution)
• Compatibility: Compatible with standard laboratory dispensing pens and micro-dispensers for 3 ml cartridges (dispensing pen/injector is not included in the package)
• Storage Conditions: Store at 2–8 °C in a dark, refrigerated environment. Do not freeze. Maintain standard laboratory cold-chain protocols to preserve compound stability.

Scientific References & Literature

• Campbell, R. M., et al. Enhanced stability and biological activity of tetrasubstituted GHRH analogs in cell culture and enzymatic degradation models. Peptides, 1997.
• Teichman, S. L., et al. Prolonged stimulation of growth hormone axis by selective synthetic peptides in cell models and neuroendocrine assays. Journal of Clinical Endocrinology & Metabolism, 2006.
• Alba, M., et al. In vitro comparison of GHRH analogs and secretagogues on somatotroph signaling and pulse kinetics. Neuroendocrinology, 2004.
• Frohman, L. A., & Jansson, J. O. Growth hormone-releasing hormone: In vitro receptor signaling, intracellular transduction, and regulation of pituitary function. Endocrine Reviews, 1986.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). The stabilized peptide solution and mechanical cartridge are not drugs, medicines, muscle-building agents, weight-loss products, dietary supplements, or medical devices, and are not intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory infrastructure to safely handle research substances, and are fully conversant with all relevant laboratory safety protocols. The seller assumes no liability for any use contrary to these terms.