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Dermorphin 5mg

Dermorphin 5mg

35,90 €

  • Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only / in vitro). It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.
  • Form & Contents: Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.
  • Recommended Storage: To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2–8 °C (recommended at -20 °C for long-term storage).
  • Illustrative Product Image: Product images are for illustrative purposes only. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.
Product code: DR5 Category:

10 in stock

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Description

Dermorphin

Synthetic heptapeptide for in vitro research on μ-opioid receptor (MOR) affinity and binding kinetics

Overview & Mechanism of Action (In Vitro)

Dermorphin is a synthetic heptapeptide with the sequence (Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2), originally isolated from the skin secretions of South American phyllomedusine frogs. In molecular biology and biochemical research, it serves as a prominent model for studying the stereochemical properties of D-amino acid-containing peptides and their receptor binding dynamics:

  • High-Affinity μ-Opioid Receptor (MOR) Activation: Highly selective binding to the orthosteric site of Gi/o-protein coupled μ-opioid receptors with negligible cross-reactivity for δ (DOR) and κ (KOR) receptor subtypes.
  • Adenylate Cyclase Inhibition: Assessment of intracellular cyclic adenosine monophosphate (cAMP) suppression in transfected cellular models (e.g., CHO or HEK293 cell lines stably expressing recombinant MOR).
  • β-Arrestin Signaling & Receptor Desensitization: Investigation of biased agonism, receptor internalization profiles, and G-protein coupled receptor kinase (GRK) phosphorylation kinetics.

The incorporation of a D-Ala residue at the second position of the peptide backbone provides pronounced resistance against aminopeptidases and endogenous proteolytic degradation in laboratory media.

Technical & Chemical Specifications

  • Classification: Research Peptide / Selective μ-Opioid Receptor Agonist (MOR)
  • Amino Acid Sequence: Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2
  • Form: Sterile lyophilized white powder (cake)
  • Molecular Weight Identification: Confirmed via Mass Spectrometry (MS)
  • Recommended Reconstitution Solvent: Sterile bacteriostatic water or phosphate-buffered saline (PBS)
  • Storage Conditions: Store long-term at -20 °C in a dry, dark environment. Following reconstitution, keep refrigerated at 2–8 °C and utilize within standard experimental protocol timelines.

Scientific References & Literature

  • Montecucchi, P. C., et al. Structure and synthesis of dermorphin, an opioid heptapeptide with high affinity for mu-receptors. International Journal of Peptide and Protein Research, 1981.
  • Erspamer, V., et al. Opioid peptides in the skin of Phyllomedusa: Structure-activity relationships and receptor pharmacology. Peptides, 1989.
  • Amiche, M., et al. D-amino acid-containing peptides from amphibian skin: Biosynthesis, stereochemistry, and receptor selectivity. Biochimica et Biophysica Acta, 1998.
  • Melchiorri, P., & Negri, L. The dermorphin peptide family: Molecular and functional characterization in model receptor systems. General Pharmacology, 1996.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

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