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GLP-3 R3T

GLP-3 R3T

From 49,90 €

  • Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only / in vitro). It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.
  • Form & Contents: Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.
  • Recommended Storage: To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2–8 °C (recommended at -20 °C for long-term storage).
  • Illustrative Product Image: Product images are for illustrative purposes only. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.
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Description

GLP-3 R3T

Synthetic peptide tri-agonist for in vitro research of metabolic receptor pathways

Overview & Mechanism of Action (In Vitro)

GLP-3 R3T is a synthetic peptide compound developed for biochemical and pharmacological research. In laboratory models, it is investigated as a selective multi-target agonist with affinity for three distinct classes of G-protein coupled receptors (GPCRs):

  • GLP-1 receptor (Glucagon-Like Peptide-1 receptor): Modulation of intracellular cascades associated with adenylate cyclase activation and cAMP synthesis stimulation.
  • GIP receptor (Glucose-Dependent Insulinotropic Polypeptide receptor): Synergistic cellular interactions influencing carbohydrate and lipid signaling pathways.
  • Glucagon receptor (GCGR): Investigation of binding dynamics in hepatic cell lines and its impact on energy homeostasis signaling.

The peptide backbone features an engineered amino acid sequence conjugated to a hydrophobic di-acid lipid moiety. In experimental environments, this structural modification enhances stability against proteolytic degradation by the DPP-4 enzyme (dipeptidyl peptidase-4) and provides an extended half-life during kinetic assays.

Technical & Chemical Specifications

  • Classification: Research Peptide / Tri-Agonist (GLP-1R / GIPR / GCGR)
  • Form: Sterile lyophilized white powder (cake)
  • Molecular Weight Identification: Confirmed via Mass Spectrometry (MS)
  • Recommended Reconstitution Solvent: Sterile bacteriostatic water or phosphate-buffered saline (PBS)
  • Storage Conditions: Store long-term at -20 °C in a dry, dark environment. Following reconstitution, keep refrigerated at 2–8 °C and utilize within standard experimental protocol timelines.

Scientific References & Literature

  • Coskun, T., et al. LY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist: In vitro pharmacology and mechanism of action. Cell Metabolism, 2022.
  • Jastreboff, A. M., et al. Triple-Hormone-Receptor Agonist Mechanisms in Metabolic Signaling Systems. The New England Journal of Medicine, 2023.
  • Finan, B., et al. Chemical optimization and receptor selectivity profiles of multi-agonist peptide platforms. Nature Reviews Drug Discovery, 2020.
  • Knerr, P. J., et al. Next-generation multi-receptor glucagon-family peptides: Structural insights and in vitro activity profiles. Bioorganic & Medicinal Chemistry, 2021.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

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