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Kisspeptin

Kisspeptin

From 27,90 €

  • Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only / in vitro). It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.
  • Form & Contents: Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.
  • Recommended Storage: To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2–8 °C (recommended at -20 °C for long-term storage).
  • Illustrative Product Image: Product images are for illustrative purposes only. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.
Product code: KS5 Category:
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Description

Kisspeptin-10

Synthetic C-terminal decapeptide amide (metastin 45–54 / KISS1 fragment) for in vitro research on KISS1R (GPR54) activation, pulsatile GnRH secretion regulation, hypothalamic-pituitary signaling, and tumor invasion suppression

Overview & Mechanism of Action (In Vitro)

Kisspeptin-10 (also designated as KISS1 [112–121] amide or Metastin [45–54]) is a synthetic biologically active decapeptide with the sequence (Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2), representing the minimum functional C-terminal core sequence of the endogenous KISS1 gene required for full receptor binding potency. Characterized by a high ratio of aromatic and hydrophobic amino acid residues (Trp, Phe, Tyr, Leu), it serves in molecular endocrinology, reproductive biology, and oncology models as a primary standard for investigating neuroendocrine regulation and cell migration:

  • High-Affinity Activation of the KISS1R Receptor (GPR54): Selective binding to Gαq/11 protein-coupled receptors, driving phospholipase C (PLC) activation, generating inositol trisphosphate (IP3) and diacylglycerol (DAG), and triggering rapid intracellular calcium (Ca2+) mobilization.
  • Regulation of GnRH Pulsatility in Hypothalamic Networks: Direct excitation and depolarization of GnRH-expressing neurons, promoting the pulsatile release of gonadotropin-releasing hormone (GnRH) and downstream luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion cascades in vitro.
  • Suppression of Metastatic Potential & Cellular Motility: Downregulation of matrix metalloproteinases (MMP-2 and MMP-9) and inhibition of cell invasion in aggressive metastatic tumor cell lines without reducing basal cell viability.
  • Modulation of MAPK / ERK Signaling Pathways: Activation of phosphorylation cascades (ERK1/2 and p38 MAPK) involved in cellular differentiation and signal integration across distinct tissue models.

Technical & Chemical Specifications

  • Classification: Research Decapeptide / KISS1R (GPR54) Receptor Agonist / Metastin (45–54) Amide
  • Amino Acid Sequence: H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 (YNWNSFGLRF-NH2)
  • Form: Sterile lyophilized white powder (cake)
  • Component Identification: Verified via Mass Spectrometry (MS) and analytical HPLC
  • Recommended Reconstitution Protocol (Hydrophobic Peptide): Due to the high proportion of hydrophobic and aromatic residues (especially tryptophan and phenylalanine), aqueous solubility can be restricted. For optimal and rapid dissolution without aggregation, the use of sterile dilute acetic acid water (0.1% to 1.0% solution / acetic acid water) or sterile bacteriostatic water is recommended. Allow the solvent to flow slowly down the vial wall and let the cake hydrate passively without vigorous shaking or vortexing.
  • Storage Conditions: Store long-term at -20 °C in a dry, dark environment. Following reconstitution, keep refrigerated at 2–8 °C in accordance with standard laboratory protocols.

Scientific References & Literature

  • Kotani, M., et al. The metastasis suppressor gene KiSS-1 encodes a peptide that activates GPR54 with high affinity. Journal of Biological Chemistry, 2001.
  • Messager, S., et al. Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. Proceedings of the National Academy of Sciences, 2005.
  • Ohtaki, T., et al. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature, 2001.
  • Roa, J., et al. Kisspeptins and the control of gonadotropin secretion: Molecular and cellular mechanisms in hypothalamic networks. Human Reproduction Update, 2008.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

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