Description

Tesamorelin – Pre-filled Laboratory Cartridge for In Vitro Research (10 mg / 3 ml)

Synthetic -terminally modified 44-amino acid growth hormone-releasing hormone analogue (trans-3-hexenoyl-hGHRH 1-44) in a pre-formulated stabilized buffered solution for in vitro research on GHRH receptor signaling, cAMP/PKA cascades, somatotropic transcription regulation, and cellular lipolytic pathways

Overview & Mechanism of Action (In Vitro)

Tesamorelin is a synthetic bioactive polypeptide consisting of the complete 44-amino acid sequence of human GHRH stabilized by an -terminal trans-3-hexenoyl group. This hydrophobic modification confers enhanced enzymatic stability against dipeptidyl peptidase-4 (DPP-4) cleavage while fully maintaining target receptor affinity. In molecular endocrinology, cellular physiology, and metabolic biochemistry, it serves as a primary reference standard for investigating the somatotropic axis and lipid turnover pathways across cell cultures:

• High-Affinity GHRH Receptor Engagement: Selectively binds to transmembrane GHRH receptors coupled to  proteins on pituitary somatotrophs, stimulating intracellular cyclic adenosine monophosphate () synthesis and protein kinase A (PKA) activation.
• Stimulation of Growth Hormone Transcription & Pulsatile Exocytosis: Induces growth hormone gene expression and supports vesicular packaging without disrupting natural somatostatinergic negative feedback loops.
• Modulation of Lipolytic Signaling in Adipocyte Models: In primary adipocyte cultures, it stimulates hormone-sensitive lipase (HSL) activity and upregulates fatty acid oxidation enzymes via downstream GH and IGF-1 signaling cascades in vitro.
• Support of Cellular Viability & Protein Synthesis: Induces IGF-1 transcription and promotes anabolic translation pathways across cultured hepatic and myoblast cell lines in vitro.
• Pre-formulated Format for Precise Laboratory Dispensing: The stabilized liquid matrix within a 3 ml cartridge eliminates manual reconstitution steps, ensuring exceptional homogeneity and concentration consistency for automated micro-dispensing systems.

Technical & Chemical Specifications

• Classification: Synthetic GHRH (1-44) Analogue / Somatotropic Bioregulator / Research Peptide Solution (RUO)
• Product Format: Pre-filled calibrated laboratory cartridge (3 ml volume)
• Compound Strength: 10 mg / 3 ml (approx. 3.33 mg/ml concentration)
• Amino Acid Sequence:
• Chemical Name:
• Molecular Formula:
• Molecular Weight:
• Form: Sterile stabilized clear solution / Ready-to-Use (RTU)
• Solution Matrix: Sterile buffered isotonic solution for laboratory use (pH-optimized, requires no reconstitution or dilution)
• Compatibility: Compatible with standard laboratory dispensing pens and micro-dispensers for 3 ml cartridges (dispensing pen/injector is not included in the package)
• Storage Conditions: Store at 2–8 °C in a dark, refrigerated environment. Do not freeze. Maintain standard laboratory cold-chain protocols to preserve compound stability.

Scientific References & Literature

• Ferdinand, R. C., et al. Tesamorelin: In vitro receptor kinetics, signaling specificity, and metabolic regulation in somatotroph and adipocyte cell models. Endocrine Reviews, 2011.
• Falutz, J., et al. Metabolic actions of growth hormone-releasing factor analog tesamorelin: Mechanisms of lipid turnover and cellular signaling in vitro. Journal of Clinical Endocrinology & Metabolism, 2008.
• Clemmons, D. R., et al. Mechanisms of action of GHRH and its synthetic analogs on somatotroph transcription and downstream lipolysis in vitro. Growth Hormone & IGF Research, 2014.
• Stanley, T. L., & Grinspoon, S. K. Regulation of visceral adipocyte signaling and hepatic lipid oxidation by synthetic GHRH analogs in cellular systems. Biochimica et Biophysica Acta, 2015.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). The stabilized peptide solution and mechanical cartridge are not drugs, medicines, fat-loss agents, weight-loss products, dietary supplements, or medical devices, and are not intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory infrastructure to safely handle research substances, and are fully conversant with all relevant laboratory safety protocols. The seller assumes no liability for any use contrary to these terms.