Description

Adamax

Synthetic bifunctionally modified Semax peptide analogue (N-acetyl-Semax adamantylamide) for in vitro research on TrkB receptor activation, BDNF and NGF expression modulation, synaptogenesis, and neurotrophic signaling pathways

Overview & Mechanism of Action (In Vitro)

Adamax is an advanced synthetic derivative of the neuropeptide Semax (an ACTH 4–10 fragment linked to a C-terminal Pro-Gly-Pro tripeptide), engineered with N-terminal acetylation (Ac) and a terminal C-terminal adamantyl moiety (adamantan-1-ylamide). This dual functionalization significantly increases lipophilicity, biomembrane permeability, and proteolytic resistance against endopeptidases and carboxypeptidases in laboratory media. In cellular neurobiology, molecular neuropsychopharmacology, and tissue engineering, it serves as a high-potency reference standard for studying neurocognitive and regenerative cascades:

• Potent Induction of Neurotrophin Expression (BDNF & NGF): Marked upregulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) transcription and translation in primary cortical and hippocampal neuronal networks.
• Activation of the TrkB / MAPK / PI3K-Akt Axis: Increased phosphorylation of the receptor tyrosine kinase TrkB, stimulating downstream intracellular cascades governing neuronal survival, synaptic structural scaffolding, and long-term potentiation (LTP).
• Modulation of Monoaminergic Pathways: Investigating regulation of dopamine and serotonin metabolic dynamics in neurochemical cell models without addictive signaling pathways.
• Mitochondrial Protection & Excitotoxicity Attenuation: Prevention of oxidative degradation and apoptotic cell death induced by excess glutamate receptor (NMDA) activation in simulated in vitro ischemic stress models.

Technical & Chemical Specifications

• Classification: Research Peptide / Dual-Modified Stabilized Semax Analogue
• Structure & Chemical Name: Ac-Met-Glu-His-Phe-Pro-Gly-Pro-Adamantylamide (Ac-Semax-Adamantane)
• Form: Sterile lyophilized white to off-white powder (cake)
• Component Identification: Verified via Mass Spectrometry (MS) and analytical HPLC
• Recommended Reconstitution Protocol (Adamantyl Group Dynamics): Due to the bulky, lipophilic C-terminal adamantyl anchor, solubility requires careful handling. Sterile bacteriostatic water or sterile phosphate-buffered saline (PBS) is recommended; in cases of slower dissolution, a mildly acidified sterile solution (0.1% acetic acid water) can be utilized. Allow the cake to hydrate passively without vigorous agitation.
• Storage Conditions: Store long-term at -20 °C in a dry, dark environment. Following reconstitution, keep refrigerated at 2–8 °C in accordance with standard laboratory protocols.

Scientific References & Literature

• Ashmarin, I. P., et al. Semax and its extended C-terminal peptide derivatives: Neurotrophic effects and mechanisms of action. Neurochemical Journal, 2005.
• Dolotov, O. V., et al. The synthetic peptide Semax and its analogues stimulate the expression of BDNF and its TrkB receptor in rat brain and cell cultures. Journal of Neurochemistry, 2006.
• Grivennikov, I. A., et al. Influence of ACTH-like peptide analogues on nerve growth factor and differentiation markers in primary neuronal lineages. Molecular and Cellular Neuroscience, 2008.
• Tsvetkov, D. E., et al. Structure-activity relationships and enzymatic stability of adamantane-containing bioactive peptide analogues. Bioorganic & Medicinal Chemistry Letters, 2012.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.