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Enclomiphene Capsules

Enclomiphene Capsules

49,90 €

  • Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only / in vitro). It is not a medicinal product, food, or dietary supplement. The compound in a solid carrier is not intended for application, consumption, or any therapeutic use in humans or animals.
  • Form & Presentation: Contains precisely pre-weighed research material within an enclosed capsule carrier for convenient laboratory handling.
  • Recommended Storage: Store in the original sealed container in a cool, dry, and dark place at temperatures up to 20 °C. Protect from moisture and direct sunlight.
  • Illustrative Product Image: Product images are for illustrative purposes only. Capsule coloration, packaging format, or laboratory label design may vary depending on the production batch.
Product code: ENC25 Category:

10 in stock

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Description

Enclomiphene – Research Capsules for Laboratory Purposes (25 mg / capsule, 60 count)

Pure synthetic (E)-stereoisomer of a non-steroidal selective estrogen receptor modulator (SERM) in a solid analytical matrix for in vitro research on estrogen receptor antagonism (ERα/ERβ), HPG axis gonadotropic signaling, and cellular proliferation kinetics

Overview & Mechanism of Action (In Vitro)

Enclomiphene ((E)-clomiphene citrate) is a highly purified stereoisomer of a non-steroidal triphenylethylene derivative, characterized by a potent and selective antagonistic profile at estrogen receptors (ERα and ERβ) in endocrine and target cellular models. In cellular endocrinology, reproductive biology, and molecular oncology, it serves as a primary reference standard for mapping estrogenic negative feedback loops, gonadotropic transcriptional regulation, and hormone-responsive cell signaling:

  • Selective Estrogen Receptor (ER) Antagonism: Unlike its zuclomiphene counterpart (which displays partial estrogen receptor agonism), enclomiphene acts as a pure competitive ER antagonist in hypothalamic-pituitary cell lines in vitro.
  • Modulation of HPG Axis Feedback In Vitro: Disables estrogen-mediated negative feedback mechanisms in anterior pituitary cell cultures, leading to the upregulation of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) subunit gene transcription.
  • Regulation of Proliferation in Hormone-Sensitive Lines: Inhibits estrogen-induced cell cycle progression in receptor-positive lines (e.g., MCF-7), inducing cell cycle arrest in the G0/G1 phase.
  • Isomeric Purity & Matrix Stability: The standardized solid matrix formulation prevents chemical degradation, ensuring stereoisomeric integrity (>99% (E)-isomer) for reproducible laboratory bioassays.

Technical & Chemical Specifications

  • Classification: Selective Estrogen Receptor Modulator (SERM) / Non-Steroidal Standard in Solid Matrix (RUO)
  • Chemical Name: 2-[4-[(E)-2-chloro-1,2-diphenylethenyl]phenoxy]-N,N-diethylethanamine; 2-hydroxypropane-1,2,3-tricarboxylic acid (citrate salt)
  • Molecular Formula: C26H28ClNO⋅C6H8O7
  • Molecular Weight: 598.09 g/mol (citrate salt) / 405.96 g/mol (free base)
  • Active Content: 25 mg per capsule (±2%)
  • Packaging Unit: 60 research capsules in a laboratory container with integrated desiccant
  • Form: Solid reagent matrix / encapsulated standard
  • Component Identification: Verified via Analytical HPLC (confirming stereoisomeric purity >99%) and Mass Spectrometry (MS / NMR)
  • Recommended Reconstitution Protocol: Capsule contents are intended for dissolution in suitable laboratory solvents (e.g., DMSO, ethanol, or calibrated assay buffers) to prepare working concentrations for in vitro cell testing.
  • Storage Conditions: Store at 15–25 °C in a dry, dark environment in the tightly sealed original container with desiccant. For long-term archiving of analytical standards, storage at -20 °C is recommended.

Scientific References & Literature

  • Hill, S., et al. Enclomiphene citrate for the restoration of hormonal signaling pathways: In vitro and cellular pharmacology of isolated isomers. Endocrine Reviews, 2014.
  • Wiehle, R. D., et al. Relative estrogenic and antiestrogenic activities of enclomiphene and zuclomiphene in cellular receptor assays. Reproductive Biology and Endocrinology, 2014.
  • Rodriguez, K. M., et al. Selective estrogen receptor modulators in cellular neuroendocrinology and reproductive models in vitro. Therapeutic Advances in Urology, 2019.
  • Goldstein, G., et al. Differential effects of clomiphene isomers on gonadotropin secretion in primary pituitary cell cultures. The Journal of Urology, 2016.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

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