Description

GLP-2 SURV

Synthetic bioactive acylated peptide dual agonist of GLP-1R and GCGR (glucagon receptor) for in vitro research on convergent metabolic signaling, intracellular cAMP modulation, hepatic lipid clearance, anti-inflammatory pathways, and mitochondrial bioenergetics

Overview & Mechanism of Action (In Vitro)

GLP-2 SURV (a research code designated for an advanced acylated dual peptide analogue derived from the glucagon peptide backbone with a hydrophobic diacid lipid conjugate) is a synthetic polypeptide designed as a high-affinity co-agonist targeting both the glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR). Structural acylation provides increased binding stability in culture media and exceptional resistance against enzymatic cleavage by dipeptidyl peptidase-4 (DPP-4) and neutral endopeptidases (NEP 24.11). In molecular gastroenterology, cellular hepatology, and bioenergetics, it serves as a primary reference standard for dissecting dual receptor integration and cellular metabolic control:

• Simultaneous GLP-1R and GCGR Pathway Activation: Coordinated engagement of both G-protein coupled receptors (Gαs) triggers synergistic adenylyl cyclase activation, producing a rapid rise in intracellular cAMP that recruits downstream PKA and Epac cascades.
• Reduction of Hepatic Lipid Accumulation & Fibrotic Signaling: Glucagon receptor signaling in primary hepatocyte models stimulates mitochondrial fatty acid uptake (β-oxidation) while suppressing the phenotypic activation of hepatic stellate cells (HSCs), mitigating collagen synthesis in vitro.
• Mitochondrial Respiration & Oxidative Stress Mitigation: Improves mitochondrial chain integrity and oxygen consumption rates in substrate-challenged cell lines, reducing intracellular reactive oxygen species (ROS) accumulation.
• Anti-Inflammatory Modulation via GLP-1R: Downregulates NF-κB phosphorylation and limits the release of inflammatory chemokines and cytokines in macrophage and vascular endothelial cell cultures.

Technical & Chemical Specifications

• Classification: Research Peptide / Dual GLP-1R & GCGR Agonist (Acylated Glucagon-Derived Analogue)
• Form: Sterile lyophilized white powder (cake)
• Component Identification: Verified via Mass Spectrometry (MS) and analytical HPLC (≥98% purity)
• Recommended Reconstitution Solvent: Sterile bacteriostatic water, sterile deionized water, or sterile phosphate-buffered saline (PBS, pH 7.4–8.0). A mildly basic physiological buffer may be used to achieve complete reconstitution at higher stock concentrations.
• Storage Conditions: Store long-term at -20 °C in a dry, dark environment. Following reconstitution, keep refrigerated at 2–8 °C in accordance with standard laboratory protocols.

Scientific References & Literature

• Finan, B., et al. Chemical hybridization of glucagon and GLP-1 yields a dual-agonist with therapeutic potential in metabolic cellular models. Nature Medicine, 2015.
• Sánchez-Garrido, M. A., et al. Glucagon and GLP-1 dual receptor agonism as an integrated mechanism for hepatic energy reprogramming. Journal of Biological Chemistry, 2017.
• Zimmermann, T., et al. The dual GLP-1/glucagon receptor agonist targets hepatic steatosis and inflammation in primary hepatocyte cocultures. Hepatology Communications, 2022.
• Trevaskis, J. L., et al. Glucagon receptor signaling coordinates with GLP-1 to enhance cellular lipid utilization and reduce fibrotic gene expression. Molecular Metabolism, 2020.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.