• Fast shipping across Europe
  • High-quality and 100% pure peptides for research purposes
Tesamorelin

Tesamorelin

From 35,90 €

  • Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only / in vitro). It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.
  • Form & Contents: Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.
  • Recommended Storage: To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2–8 °C (recommended at -20 °C for long-term storage).
  • Illustrative Product Image: Product images are for illustrative purposes only. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.
Product code: TSM5 Category:
Share on social media

Description

Tesamorelin

Synthetic N-terminally acylated GHRH peptide analogue (trans-3-hexenoyl-hGHRH 1–44 amide) for in vitro research on GHRH-R activation, somatotroph signaling, pulsatile growth hormone secretion, and selective visceral adipocyte lipolysis

Overview & Mechanism of Action (In Vitro)

Tesamorelin (also designated as trans-3-hexenoyl-GHRH [1–44] amide) is a synthetic 44-amino acid polypeptide terminated with a C-terminal amide, modified at the N-terminus with a hydrophobic trans-3-hexenoic acid group. This hydrophobic acyl moiety provides enzymatic resistance against dipeptidyl peptidase-4 (DPP-4) cleavage, significantly increasing peptide integrity in laboratory media. In cell biology, molecular endocrinology, and metabolic research, it serves as a primary reference model for studying the somatotropic axis and lipid mobilization pathways:

  • Selective Activation of the Pituitary GHRH-R Receptor: High-affinity binding to Gαs protein-coupled receptors on anterior pituitary somatotrophic cell membranes.
  • Stimulation of GH Synthesis & Pulsatile Secretion: Activation of the intracellular cAMP / PKA signaling cascade and modulation of Ca2+ flux, promoting growth hormone gene expression and physiological exocytosis while maintaining endogenous feedback mechanisms.
  • Selective Lipolysis in Visceral Adipocytes: Investigating downstream triglyceride breakdown cascades in deep visceral adipose tissue (VAT) models via hormone-sensitive lipase (HSL) activation in vitro.
  • Enzymatic Stability via Hydrophobic N-Terminal Modification: Extended structural stability in solution due to the lipophilic hexenoyl anchor preventing rapid N-terminal enzymatic degradation.

Technical & Chemical Specifications

  • Classification: Research Peptide / Hydrophobic GHRH (1–44) Amide Analogue
  • Amino Acid Sequence: trans-3-Hexenoyl-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2
  • Form: Sterile lyophilized white powder (cake)
  • Component Identification: Verified via Mass Spectrometry (MS) and analytical HPLC
  • Recommended Reconstitution Protocol (Hydrophobic Peptide): Due to the high hydrophobicity of the N-terminal hexenoyl group, dissolution requires careful handling. The use of sterile dilute acetic acid water (0.1% to 1.0% solution) or sterile bacteriostatic water is recommended. Allow the solvent to flow gently down the vial wall and let the cake hydrate spontaneously without vigorous shaking or vortexing to prevent aggregation and foaming.
  • Storage Conditions: Store long-term at -20 °C in a dry, dark environment. Following reconstitution, keep refrigerated at 2–8 °C in accordance with standard laboratory protocols.

Scientific References & Literature

  • Falutz, J., et al. Metabolic effects of a growth hormone-releasing factor analogue, tesamorelin, in cell models and clinical investigations. Journal of Clinical Endocrinology & Metabolism, 2008.
  • Ferdinandi, E. S., et al. Nonclinical pharmacology and metabolic stability of (hexenoyl)GHRH (Tesamorelin). Regulatory Toxicology and Pharmacology, 2007.
  • Stanley, T. L., & Grinspoon, S. K. Effects of growth hormone-releasing hormone on visceral adiposity and somatotroph dynamics. Pituitary, 2010.
  • Clemmons, D. R., et al. Mechanism of action of Tesamorelin: In vitro receptor affinity and regulation of growth hormone synthesis. Endocrine Reviews, 2014.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

Latest products

Get 10% Off Your First Order

Subscribe to our newsletter and we will immediately send you a discount code for your first order of research materials. Get exclusive access to special offers, restock alerts, and expert updates.