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Melanotan I 10mg

Melanotan I 10mg

29,90 €

  • Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only / in vitro). It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.
  • Form & Contents: Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.
  • Recommended Storage: To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2–8 °C (recommended at -20 °C for long-term storage).
  • Illustrative Product Image: Product images are for illustrative purposes only. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.
Product code: MT1 Category:

10 in stock

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Description

Melanotan I

Synthetic linear α-MSH analog for in vitro research on melanocortin receptor activation and enzymatic stimulation of melanogenesis

Overview & Mechanism of Action (In Vitro)

Melanotan I (also recognized as Afamelanotide or [Nle4, D-Phe7]-α-MSH) is a synthetic linear tridecapeptide with the sequence (Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2). It serves as a metabolically stabilized analog of natural alpha-melanocyte-stimulating hormone (α-MSH). In biochemical and dermatological research, it represents a selective tool for examining melanocortin system signaling cascades:

  • High-Affinity MC1R Receptor Binding: Selective agonism at the melanocortin-1 receptor (MC1R) coupled to Gs-proteins on epidermal melanocyte membranes.
  • cAMP / PKA / CREB Pathway Activation: Stimulation of adenylate cyclase leading to elevated intracellular cAMP levels, phosphorylation of the CREB transcription factor, and downstream expression of microphthalmia-associated transcription factor (MITF).
  • Upregulation of Melanogenic Enzymes: In vitro induction of transcription and catalytic activity of tyrosinase and tyrosinase-related proteins (TRP-1, TRP-2), which govern eumelanin biosynthesis.
  • Structural & Enzymatic Stability: Substitution of methionine with norleucine (Nle4) and L-phenylalanine with D-phenylalanine (D-Phe7) confers enhanced resistance against oxidative degradation and serum endopeptidase cleavage relative to native α-MSH.

Technical & Chemical Specifications

  • Classification: Research Peptide / Selective Melanocortin Receptor Agonist (MC1R)
  • Amino Acid Sequence: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
  • Form: Sterile lyophilized white powder (cake)
  • Molecular Weight Identification: Confirmed via Mass Spectrometry (MS)
  • Recommended Reconstitution Solvent: Sterile bacteriostatic water or phosphate-buffered saline (PBS)
  • Storage Conditions: Store long-term at -20 °C in a dry, dark environment. Following reconstitution, keep refrigerated at 2–8 °C and utilize within standard experimental protocol timelines.

Scientific References & Literature

  • Sawyer, T. K., et al. 4-Norleucine, 7-D-phenylalanine-alpha-melanocyte-stimulating hormone: A highly potent alpha-melanotropin with prolonged biological activity. Proceedings of the National Academy of Sciences, 1980.
  • Dorff, P. H., et al. The melanocortin-1 receptor: Molecular pharmacology and intracellular signaling in human melanocytes. Pigment Cell & Melanoma Research, 2008.
  • Abdel-Malek, Z. A., et al. Alpha-MSH and its synthetic analogs stimulate melanocyte proliferation and melanogenesis via the cAMP pathway in vitro. Journal of Cell Science, 1995.
  • Hadley, M. E., et al. Comparative biology of synthetic melanotropins: Potency and receptor selectivity in cultured cellular models. Peptides, 1996.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

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