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Ipamorelin

Ipamorelin

From 19,90 €

  • Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only / in vitro). It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.
  • Form & Contents: Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.
  • Recommended Storage: To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2–8 °C (recommended at -20 °C for long-term storage).
  • Illustrative Product Image: Product images are for illustrative purposes only. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.
Product code: IP5 Category:
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Description

Ipamorelin

Synthetic pentapeptide for in vitro research on selective growth hormone secretagogue receptor (GHS-R1a) signaling

Overview & Mechanism of Action (In Vitro)

Ipamorelin is a synthetic pentapeptide with the sequence (Aib-His-D-2-Nal-D-Phe-Lys-NH2) belonging to the third generation of peptide secretagogues. In molecular endocrinology and cellular biology, it serves as a highly selective reference ligand for investigating ghrelinergic receptor pathways without off-target cross-reactivity:

  • Highly Selective GHS-R1a Activation: Specific binding to the Gq-protein coupled receptor on isolated pituitary somatotrope cell lines without cross-activating pathways governing the release of ACTH, cortisol, prolactin, FSH, or LH.
  • Intracellular Calcium Cascades: Activation of phospholipase C (PLC), generating inositol trisphosphate (IP3) and diacylglycerol (DAG), which facilitates measurable intracellular calcium ion (Ca2+) mobilization.
  • Enzymatic & Structural Stability: Incorporation of the non-proteinogenic amino acid Aib (α-aminoisobutyric acid), D-isomers (D-2-Nal, D-Phe), and C-terminal amidation confers pronounced resistance against dipeptidyl peptidases and tissue endoproteases.

This distinct selectivity profile makes it a crucial laboratory tool for isolating somatotropic axis dynamics without interference from other neuroendocrine axes.

Technical & Chemical Specifications

  • Classification: Research Peptide / Selective GHS-R1a Agonist (3rd Generation)
  • Amino Acid Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH2
  • Form: Sterile lyophilized white powder (cake)
  • Molecular Weight Identification: Confirmed via Mass Spectrometry (MS)
  • Recommended Reconstitution Solvent: Sterile bacteriostatic water or phosphate-buffered saline (PBS)
  • Storage Conditions: Store long-term at -20 °C in a dry, dark environment. Following reconstitution, keep refrigerated at 2–8 °C and utilize within standard experimental protocol timelines.

Scientific References & Literature

  • Raun, K., et al. Ipamorelin, the first selective growth hormone secretagogue: In vitro characterization and receptor binding profiles. European Journal of Endocrinology, 1998.
  • Smith, R. G., et al. Development of selective non-peptide and peptide growth hormone secretagogues: Molecular mechanisms and specificity. Endocrine Reviews, 2005.
  • Kojima, M., & Kangawa, K. Ghrelin and the GHS-R1a signaling network: Structural insights and receptor pharmacology. Physiological Reviews, 2005.
  • Jimenez-Reina, L., et al. Morphological and functional response of cultured somatotropes to selective GHS-R agonists. Histology and Histopathology, 2002.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

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