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Cagrilintide

Cagrilintide

From 52,90 €

  • Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only / in vitro). It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.
  • Form & Contents: Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.
  • Recommended Storage: To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2–8 °C (recommended at -20 °C for long-term storage).
  • Illustrative Product Image: Product images are for illustrative purposes only. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.
Product code: CGL5 Category:
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Description

Cagrilintide

Synthetic long-acting amylin analogue and non-selective AMYR / CTR agonist for in vitro research on metabolic signaling, satiety homeostasis, and neuroendocrine pathways

Overview & Mechanism of Action (In Vitro)

Cagrilintide is a synthetic acylated peptide analogue of the endogenous pancreatic peptide amylin (islet amyloid polypeptide, IAPP). It incorporates specific amino acid substitutions to eliminate the propensity for amyloid fibril aggregation, coupled with a C20 fatty diacid-linker moiety to ensure high stability. In molecular endocrinology and neurobiological research, it functions as a defined model for investigating central satiety signaling and metabolic regulation:

  • Dual Agonism at AMYR and CTR Receptors: High-affinity activation across all amylin receptor subtypes (AMYR1–3, comprised of the calcitonin receptor CTR core complexed with receptor activity-modifying proteins RAMP1–3) as well as the calcitonin receptor (CTR) alone.
  • Activation of cAMP and Intracellular Ca2+ Signaling Cascades: Stimulation of adenylate cyclase, elevating intracellular cyclic adenosine monophosphate (cAMP) levels and triggering downstream mobilization of intracellular calcium in target cell lines.
  • Neuroendocrine & Central Pathways: Investigation of neuronal activation patterns within the brainstem (specifically the area postrema) and hypothalamic nuclei regulating energy homeostasis and gastric emptying rates in vitro.
  • Cross-Talk with Incretin Cascades (GLP-1R): Assessment of additive and synergistic metabolic signaling dynamics during concurrent activation of amylin and glucagon-like peptide-1 (GLP-1) receptor pathways.

Technical & Chemical Specifications

  • Classification: Research Peptide / Long-Acting Amylin Analogue (AMYR/CTR Dual Agonist)
  • Form: Sterile lyophilized white powder (cake)
  • Component Identification: Verified via Mass Spectrometry (MS) and analytical HPLC
  • Recommended Reconstitution Solvent: Sterile bacteriostatic water or sterile water for injection
  • Storage Conditions: Store long-term at -20 °C in a dry, dark environment. Following reconstitution, keep refrigerated at 2–8 °C and utilize within standard experimental protocol timelines.

Scientific References & Literature

  • Kruse, T., et al. The design and discovery of cagrilintide, a long-acting amylin analogue for weight management. Journal of Medicinal Chemistry, 2021.
  • Lau, J., et al. Cellular pharmacology of dual amylin and calcitonin receptor agonists: In vitro characterization of cagrilintide. Molecular Metabolism, 2022.
  • Hay, D. L., et al. Amylin receptors: Molecular composition and pharmacology of pramlintide and next-generation analogs. Pharmacological Reviews, 2015.
  • Erickson, M. R., et al. Synergistic metabolic benefits of dual amylin and GLP-1 receptor activation in model cellular systems. Cell Metabolism, 2023.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

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